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pentobarbital will reduce the extent or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with strong CYP3A4 inducers; these drugs cut down exposure t